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Botox as a Treatment for Depression: How Does It Work?


Botox is a substance derived from botulinum toxin A that temporarily paralyzes muscles.

You’re probably familiar with its use in cosmetic procedures to reduce the appearance of fine lines and wrinkles. However, it’s also been found to help with excessive sweating, migraines, and muscle spasms.

New research suggests that Botox may be an effective treatment for depression. Depression is a common mental health condition marked by ongoing feelings of hopelessness and sadness. Many people use a combination of antidepressant medications and therapy to help manage their symptoms.

However, some people can experience uncomfortable side effects from antidepressants. Often, they have to try a few different antidepressants before finding one that works well for them.

Botox may be an effective treatment option for depression used alongside antidepressants. However, research is still ongoing.

Keep reading to learn more about the recent research surrounding Botox’s use for depression, as well as the procedure and risks involved.

What does the research say?


The idea of using Botox to treat depression seems to originate in a small 2006 trial involving 10 participants with depression. They were all given a Botox injection in their glabellar frown lines. These are the lines between your eyes that tend to show up when you frown or scowl.

Two months after the injection, 9 of the participants no longer had depression symptoms. While the 10th participant still had some symptoms, they reported an improved mood.


Based on the 2006 study, a 2012 study looked at 30 people with symptoms of depression who were already receiving treatment with antidepressants.

Over 16 weeks, half of the participants received Botox injections. The other half received a placebo saline injection. This study also used the glabellar frown lines as the injection site.

Participants who received a Botox injection reported a 47.1 percent decrease in their symptoms 6 weeks after a single injection. The placebo group noted a 9.3 percent reduction.

While small, this study is still notable. It suggests that Botox may take as few as six weeks to start having a noticeable effect on mood following a single treatment. This is similar to antidepressants, which can take about two to six weeks to start working, although for some they can take up to several months to work.


A 2013 study evaluating Botox for depression added to the research. They noted that the maximal effect occurred within the first 8 weeks after treatment.


Another study involving 30 participants with depression came to similar conclusions. Participants received an injection of either Botox or placebo in their glabellar frown lines. They were evaluated every 3 weeks for 24 weeks.

Those who received the Botox injection reported improved symptoms, even after 24 weeks. This is significant: Botox’s cosmetic effects last about 12 to 16 weeks, suggesting that its effects on depression last much longer.

In the same year, another trialTrusted Source also concluded that a single treatment had a significant antidepressant effect in people with major depression.


Like previous studies, a 2017 Iranian study evaluated 28 participants with depression over 6 weeks. They too received Botox injections in their glabellar frown lines.

Botox was also used alongside their antidepressant treatment. By the end of the study, symptoms of depression improved more in the participants who received Botox compared to those who received a placebo.

What are the benefits?

While the results of these studies are promising, researchers are still trying to figure out exactly how Botox treats depression.

Initially, they thought the antidepressant effects of Botox might be related to improved appearance. Having fewer wrinkles, they hypothesized, might improve someone’s mood.

However, a 2016 review of the earlier studies found that the severity of a person’s frown lines didn’t impact their results. For example, people with very few frown lines still reported similar results. This suggests that improved appearance isn’t a factor.

A more likely explanation of the benefits of Botox for depression has to do with a “facial feedback” mechanism. Facial expressions send certain feedback to the brain. Emotions like fear, sadness, or anger can result in the contraction of muscles in the forehead that cause the glabellar frown lines.

In people who are depressed, the activity of the muscles that cause these frowns is increased. Blocking these frowning muscles with Botox may result in improved mood.


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